20α, 22ξ-Dihydroxycholesterol, an Intermediate in the Biosynthesis of Pregnenolone (3β-Hydroxypregn-5-en-20-one) from Cholesterol
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چکیده
منابع مشابه
3β-Chlorocholest-5-en-7-one
The title compound, C(27)H(43)ClO, is a steroid derivative composed of a saturated carbon fused-ring framework with an alkyl side chain. The A and C rings have chair conformations and the B and D rings assume half-chair conformations. The cholesterol side chain is fully extended with a gauche, trans conformation of the terminal methyl groups. In the crystal structure, the molecules are aligned ...
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The comparative effectiveness of subcutaneous administration of 20p·OH-P, pregnanolone and progesterone in oil to prolong gestation in rats was determined. As a result it was found that, while progesterone was shown to have activity, pregnanolone and 20j1-0H-P were ineffective in doses of 5 mg per day. ∗PMID: 4263519 [PubMed indexed for MEDLINE] Copyright c ©OKAYAMA UNIVERSITY MEDICAL SCHOOL Ac...
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The two isomeric 20(22)-olefins and the four isomeric 20,22-epoxides of cholesterol have been examined as possible intermediates in the conversion of cholesterol to pregnenolone both by crude extracts of acetone-dried bovine adrenal cortex mitochondria, and by a partially purified cytochrome P-450 specific for the side chain cleavage ( P 4 5 0 ~ ~ ~ ) . The quantities of pregnenolone (measured ...
متن کاملCholest-5-en-3β-yl N-phenylcarbamate
In the title compound, C(34)H(51)NO(2), the dihedral angle between the planes of the phenyl ring and the carbonyl group is 9.30 (2)°. No significant inter-molecular inter-actions are observed in the crystal structure. The C(5)H(11) fragment is disordered over two positions with site occupancies of 0.611 (6) and 0.389 (6).
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having conducted the experiment and analysed the data, the researcher computed the groups mean scores and variances for the test relating to the research question. as the final atep, a t-test was conodonted for the hypothesis. as noted earlier, the significance level was determined at .05 and .01 respectively. the observed t-value was higher than the critical t-value at. 5 and .01 levels. conse...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1962
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)60358-8